Abstract: Based on the problem of oil prospecting in Huimin Depression, the prospecting technology for lithological oil reservoir is studied.Combined logging and seismic as well as wavelet transform technology, the method to establish isochronic framwork of stratigraphic sequence is presented, and the space-time distribution in each belta is determined.Using multivariate composite calibration, classification of seismic facies, forward modeling and logging constrained inversion technique, we realized the description of beneficial sand body in dissimilarity sedimentation type, and formed a technical series that fit for the prospeting in Huimin area.