Abstract: the characteristics of the seismicity in history and recent years in the joint area of Shandong, Anhui and Henan Province are analyzed.Based on the historical active cycle and the evolution of seismicity gap in space, the tendency of earthquake in the region is studied.The results show that the seismicity gap formed recently(started from 1998), which the stress field is strengthening in its vicinity, may be a seismogenic gap.From the view of earthquake migration between south and north, we concluded that the area of South 34°N is an risk region of M5.0 earthquake.