Abstract: Based on the statistical and spatial analysis of earthquake disaster loss data of transportation system in Yunnan from 1998 to 2018, the law and regional difference of economic loss caused by earthquake disaster of transportation system are studied. Based on the seismic damage data of transportation system of historical earthquakes in Yunnan, the earthquake damage characteristics of transportation system are summarized. The results show that: ① The earthquake damage loss of transportation system increases with the increase of earthquake magnitude in Yunnan. And the relationship between them is a second-order polynomial rather than linear. ② The regional difference of earthquake damage loss of transportation system is obvious in Yunnan. And in the case of the same magnitude and earthquake intensity, the economic loss is the largest in Northeast Yunnan, that is the second in West Yunnan, and that is the smallest in South Yunnan. ③ The geological disasters induced by earthquake are the important reasons for aggravation of earthquake disaster of transportation system and traffic disruption.