Abstract: Based on social network analysis, this paper establishes the research network diagram of earthquake resistance and disaster prevention of lifeline engineering based on literature review of earthquake resistance and disaster prevention of Lifeline engineering, quantifies the relative research degree of its core content, and discusses the toughness of lifeline engineering system. It is found that the current research on earthquake disaster prevention of lifeline engineering focuses on "earthquake damage prediction", and a lot of research on "reliability" of lifeline engineering. Key subsystems such as "water supply network" and "transportation system" are important components of the network research of lifeline engineering. With technological progress and research development, information technology has gradually become a research hotspot. The influence of modern technologies such as "algorithm" and "geographic information system" has gradually increased, and the research on resilience around the lifeline system of building resilient cities has increased.