Abstract: The travel time of P-wave seismic phase is obtained using a 500 km long high-resolution seismic wide-angle reflection/refraction detection profile across the western edge of Ordos Basin, Yinchuan graben, Yellow River fault zone and Helan Mountain piedmont fault in the central and western part of North China Craton, and the one-dimensional crustal velocity structure model in this area is obtained by several calculation methods. The results show that the crustal velocity structure and the stratification of the inner crust interface between the Yinchuan Basin and its two sides are highly different. The Yinchuan Basin and its western section present a three-layer crustal structure. The C2 interface exists in the west of the Ordos block merely. The crustal structure shows a double-layer feature, and the variation of the inner crust velocity isoline and interface is relatively gentle, exhibiting the stable crustal structure; Along the seismic sounding section, the crustal thickness generally presents the characteristics of gradually thickening from east to west, and each block has its crustal thickness characteristics. The differences in basement structure and deep structure between Yinchuan graben and adjacent blocks are analyzed with the research results of other geophysical and geological data in this area, and their transverse differences and structural deformation characteristics in different areas are discussed. The result provides fine geophysical parameters for the in-depth understanding of the spatial differences between the central and western parts of the North China Craton and the deep/shallow structural characteristics of the weak structural belt or active structural belt.