Abstract: Yishu fault zone, which is the part of Tanlu Fault in Shandong area, is the most active one in new tectonic movement.A lot of work has been done on its differential activity, but fewer on its causes.The main activities and characteristics of the 5 faults in Yishu zone are analyzed in the paper.We rezoned the Yishu zone, and summed up the differences in their activities between different faults or different parts of one fault and their features.Based on this, the cause of the differential activity was discussed in the field of topography, fault structure, spatial combination of the faults, modern movement, deep tectonic environment, etc.