Abstract: the analogue principle in the prediction for seismic damage of building in cities is presented, which is: the damages in different kind building can not be analogized; the damages in the sites that has great difference can not be analogized; the damages in the buildings that has large difference in aseismic design can not be analogized. Based on the principle, the analogue method, formula and parameters are given. The application in the seismic damage prediction of a tier brick building of Dongying City shows that the method is reliable.